rs5744455

A meta-analysis of 21 case-control studies examining IL-13 and CD14 gene polymorphisms in allergic rhinitis (AR). The A allele of IL-13 SNP rs20541 was significantly associated with increased AR risk in Asians (OR 1.21, 95% CI 1.11-1.32, P<0.001) but not in Caucasians. No significant associations were found for IL-13 rs1800925 or CD14 rs2569190 with AR risk in either ethnic group.

This case-control association study examined the CD14 promoter -260 C>T variant (rs2569190) in 254 African American prostate cancer cases and 188 controls. The C genotypes showed marginal association with prostate cancer overall (P=0.07), but significant association in men ≥55 years (OR: 2.18, 95% CI: 1.07-4.44, P<0.05) and specifically in African Americans (OR: 2.40, 95% CI: 1.20-4.70, P<0.05), suggesting inflammatory pathway genetic variation contributes to prostate cancer susceptibility.

This functional study investigates the molecular mechanisms of the CD14 rs2569190 polymorphism in peripheral blood mononuclear cells using chromatin immunoprecipitation and allele-specific transcript quantification. The T allele of rs2569190 showed approximately twice the recruitment of serine-5-phosphorylated RNA polymerase II compared to the C allele, suggesting enhanced transcription initiation; however, transcript abundance was similar between alleles. The findings indicate that rs2569190 affects transcription initiation but not mRNA expression levels in PBMC, and suggest that endotoxin sensitivity associated with this polymorphism may depend on tissue-specific effects in hepatic or other cell types rather than myeloid CD14 expression.