rs5744454

This is a downstream gene variant variant in the CD14 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

protein measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)
Allele T
OR 0.22
p 2.0e-52
N 10,708
Large GWAS
European
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Research that mentions this SNP (1)

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Association of CD14 variant with prostate cancer in African American men
AssociationN=442Tshela E. Mason et al.(2010)· The Prostate

This case-control association study examined the CD14 promoter -260 C>T variant (rs2569190) in 254 African American prostate cancer cases and 188 controls. The C genotypes showed marginal association with prostate cancer overall (P=0.07), but significant association in men ≥55 years (OR: 2.18, 95% CI: 1.07-4.44, P<0.05) and specifically in African Americans (OR: 2.40, 95% CI: 1.20-4.70, P<0.05), suggesting inflammatory pathway genetic variation contributes to prostate cancer susceptibility.

Traits studied:Prostate cancer
PubMedDOIMetascience Observatory

About CD14

The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]

View all CD14 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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