rs2564978

This is a regulatory region variant variant in the CD55 gene.

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Research that mentions this SNP (2)

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Association of gene polymorphisms of CD55 with susceptibility to and severity of hand, foot, and mouth disease caused by enterovirus 71 in the Han Chinese population
AssociationN=381Mei Li et al.(2020)· Journal of Medical Virology

This case-control study of 180 EV71-infected children and 201 controls found that CD55 rs2564978 polymorphism is associated with susceptibility to hand, foot, and mouth disease (C vs T: OR=1.300, 95% CI 1.120-1.509) and severity of infection (TC vs TT: OR=4.523, 95% CI 2.033-10.066). Serum CD55 levels were significantly lower in EV71 HFMD patients and severe cases compared to controls and mild cases (P<0.001).

Traits studied:HFMD severityHFMD susceptibilityHand, foot, and mouth disease (EV71-caused)
PubMedDOIMetascience Observatory
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Pilot screening study of targeted genetic polymorphisms for association with seasonal influenza hospital admission
AssociationN=14,471Tonia C. Carter et al.(2018)· Journal of Medical Virology

This pilot screening study evaluated 32 SNPs in viral immune response genes for association with hospitalized seasonal influenza in adults of European ancestry using a discovery group (26 cases, 993 controls) and two validation groups (84 cases, 4,076 controls; 128 cases, 9,187 controls). The study failed to replicate the previously reported association between IFITM3 rs12252 and hospitalized influenza (P > 0.05), and a preliminary finding of association with SLFN13 rs8072510 (P = 0.0099 in discovery group) was not confirmed in validation groups.

Traits studied:Hospitalized seasonal influenzaInfluenza hospital admissionSevere influenza infection
PubMedDOIMetascience Observatory

About CD55

This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]

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Gene information from NCBI Gene. Variant classifications from ClinVar.

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