CD55

CD55 molecule (Cromer blood group)

Summary

This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]

Known Variants199 total

rsid	Position (GRCh37)	Alleles	Class	ClinVar
rs2564978	1:207,494,416	T/C	regulatory region variant	—
rs3841376	1:207,494,484	T/C	—	—
rs2526916449	1:207,495,114	A/G	—	uncertain significance
rs7542430	1:207,495,116	C/G	—	likely benign
rs1654412142	1:207,495,125	G/A	—	likely benign
rs2526916654	1:207,495,127	C/A	—	uncertain significance
rs922742365	1:207,495,128	G/A	—	likely benign
rs1238975016	1:207,495,131	C/T	—	likely benign
rs1654413389	1:207,495,134	G/A	—	likely benign
rs1473032370	1:207,495,137	C/T	—	likely benign
rs936430730	1:207,495,144	C/T	—	likely benign
rs2102369616	1:207,495,148	C/T	—	uncertain significance
rs2526916996	1:207,495,149	C/A	—	likely benign
rs1654415350	1:207,495,153	C/T	—	uncertain significance
rs1052030123	1:207,495,168	C/T	—	uncertain significance
rs1361224396	1:207,495,180	C/T	—	likely benign
rs878907674	1:207,495,215	G/A	—	uncertain significance
rs28371587	1:207,495,224	C/A	—	likely benign
rs762580313	1:207,495,227	C/T	—	likely benign
rs2526918248	1:207,495,228	G/A	—	likely benign
rs896490746	1:207,495,708	T/C	—	likely benign
rs781576624	1:207,495,721	C/T	—	likely benign
rs2526922942	1:207,495,725	A/C	—	likely pathogenic
rs746193185	1:207,495,730	A/T	—	uncertain significance
rs2526923134	1:207,495,743	C/T	—	likely benign
rs2102372579	1:207,495,750	G/A	—	uncertain significance
rs1404198072	1:207,495,756	A/G	—	uncertain significance
rs2526923464	1:207,495,766	C/G	—	uncertain significance
rs773074921	1:207,495,774	G/T	—	pathogenic
rs28371588	1:207,495,781	G/C	—	conflicting classifications of pathogenicity
rs369907962	1:207,495,795	G/T	—	pathogenic
rs757303688	1:207,495,797	G/C	—	uncertain significance
rs2102372879	1:207,495,799	A/G	—	uncertain significance
rs1654462365	1:207,495,804	G/A	—	uncertain significance
rs1654463053	1:207,495,811	C/T	—	uncertain significance
rs754637367	1:207,495,821	T/C	—	likely benign
rs869312818	1:207,495,829	G/A	—	affects
rs373306908	1:207,495,854	G/A	—	likely benign
rs776347919	1:207,495,865	T/A	—	uncertain significance
rs147474393	1:207,495,871	T/G	—	likely benign
rs1479954347	1:207,495,878	C/T	—	likely benign
rs774482588	1:207,495,881	T/C	—	likely benign
rs200552334	1:207,495,884	A/G	—	likely benign
rs2526924702	1:207,495,886	G/A	—	pathogenic
rs121909603	1:207,495,887	G/A	stop gained	pathogenic
rs1131690771	1:207,495,889	C/A	—	affects
rs376304458	1:207,495,913	G/A	—	likely pathogenic
rs752360687	1:207,495,914	T/G	—	likely pathogenic
rs370729319	1:207,495,922	T/G	—	likely benign
rs1135402918	1:207,497,903	G/A	—	pathogenic
rs28371603	1:207,497,911	C/T	—	likely benign
rs570869398	1:207,497,912	G/A	—	uncertain significance
rs376448628	1:207,497,915	G/A	—	uncertain significance
rs2526937077	1:207,497,920	A/T	—	likely benign
rs763842871	1:207,497,950	G/A	—	likely benign
rs370636091	1:207,497,980	C/T	—	likely benign
rs745869609	1:207,497,981	G/A	—	uncertain significance
rs1572869080	1:207,498,004	C/T	—	likely benign
rs779654326	1:207,498,005	C/A	—	uncertain significance
rs756646491	1:207,498,006	G/A	—	uncertain significance
rs775681350	1:207,498,035	T/C	—	uncertain significance
rs1304361116	1:207,498,044	C/T	—	likely benign
rs1222510317	1:207,498,054	T/C	—	uncertain significance
rs1395525529	1:207,498,067	A/G	—	likely benign
rs767069550	1:207,498,082	C/T	—	likely benign
rs749948551	1:207,498,098	G/A	—	uncertain significance
rs2102380467	1:207,498,100	G/A	—	uncertain significance
rs2526938349	1:207,498,109	T/G	—	likely benign
rs2102380514	1:207,498,112	A/T	—	likely benign
rs754843923	1:207,498,115	G/A	—	likely benign
rs374967395	1:207,498,949	A/G	—	benign
rs879246194	1:207,498,966	G/A	—	likely pathogenic
rs149215462	1:207,498,973	C/T	—	uncertain significance
rs2526942306	1:207,498,983	T/C	—	likely benign
rs201591726	1:207,498,985	C/T	—	uncertain significance
rs2526942382	1:207,498,991	A/G	—	uncertain significance
rs762195469	1:207,498,996	C/T	—	pathogenic
rs772957291	1:207,499,000	A/G	—	uncertain significance
rs151294032	1:207,499,001	T/C	—	likely benign
rs1458492476	1:207,499,005	C/T	—	likely pathogenic
rs753303079	1:207,499,018	C/G	—	uncertain significance
rs2526942630	1:207,499,025	C/A	—	likely benign
rs2102382979	1:207,499,028	A/G	—	uncertain significance
rs1057053700	1:207,499,041	A/G	—	uncertain significance
rs1467410958	1:207,499,052	C/T	—	likely benign
rs1346094681	1:207,499,058	T/C	—	likely benign
rs368905867	1:207,499,061	C/T	—	likely benign
rs765300495	1:207,499,062	A/G	—	uncertain significance
rs915878687	1:207,499,064	A/G	—	likely benign
rs1224525007	1:207,499,069	A/G	—	uncertain significance
rs767688671	1:207,499,077	G/A	—	likely benign
rs2526943051	1:207,499,078	C/T	—	likely benign
rs781529960	1:207,499,079	A/C	—	likely benign
rs750721259	1:207,499,080	T/C	—	likely benign
rs2526943084	1:207,499,082	C/T	—	likely benign
rs180879554	1:207,499,086	A/G	—	benign
rs1294048085	1:207,500,087	G/A	—	likely benign
rs2526947236	1:207,500,095	A/T	—	likely pathogenic
rs1222480551	1:207,500,101	A/G	—	uncertain significance
rs1053346766	1:207,500,112	C/G	—	likely benign

Showing 100 of 199 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.