rs2606345
This is a intron variant variant in the CYP1A1 gene.
▶Research that mentions this SNP (2)
▶The Association of CYP1A1 Gene With Cervical Cancer and Additional SNP–SNP Interaction in Chinese WomenAssociationN=728Shuhong Li et al.(2016)· Journal of Clinical Laboratory Analysis
This case-control study examined the association between CYP1A1 gene polymorphisms and cervical cancer risk in 728 Chinese women (360 cases, 368 controls). The rs4646903 polymorphism showed significant association with increased cervical cancer risk (OR=1.45, 95% CI 1.20-1.95 for TC+CC vs TT genotypes). A significant SNP-SNP interaction was identified between rs4646903 and rs1048943 (P=0.0107), with subjects carrying TC/CC at rs4646903 and AG/GG at rs1048943 having the highest risk (OR=2.03, 95% CI 1.42-2.89).
▶Variants in ABCB1 , TGFB1 , and XRCC1 genes and susceptibility to viral hepatitis A infection in Mexican AmericansAssociationN=6,779Lyna Zhang et al.(2012)· Hepatology
Candidate gene association study of 67 genetic variants in 27 inflammation and DNA repair genes with hepatitis A virus (HAV) infection susceptibility in 6,779 NHANES III participants (2,619 non-Hispanic whites, 2,095 non-Hispanic blacks, 2,065 Mexican Americans). Among Mexican Americans, ABCB1 rs1045642 T allele was associated with lower HAV seropositivity risk (OR=0.79, p<0.001), while TGFB1 rs1800469 and XRCC1 rs1799782 T alleles were associated with increased risk (OR=1.38 and 1.57, respectively). CAT rs769214 and CYP2E1 rs2031920 showed marginal associations with decreased and increased HAV risk, respectively.
About CYP1A1
This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
View all CYP1A1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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