rs2622590

This is a downstream gene variant variant in the XKR4 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Thyroid stimulating hormone level

Zhan M et al. “Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.” Human Molecular Genetics 23(20):5505-17 (2014)

Allele A

OR —

β 0.030

p 2.0e-10

N 1,346

Large GWAS

East Asian

About XKR4

Enables phospholipid scramblase activity. Involved in phosphatidylserine exposure on apoptotic cell surface. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

View all XKR4 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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