rs2659052

This is a upstream gene variant variant in the LOC105372441 gene.

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GWAS Catalog Trait Associations (1)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

cancer

Rashkin SR et al. “Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts.” Nature Communications 11(1):4423 (2020)
Allele G
OR 1.11
p 3.0e-8
N 475,312
Large GWAS
European
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Research that mentions this SNP (1)

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Identification of a novel prostate cancer susceptibility variant in the KLK3 gene transcript
AssociationN=21,086Kote-Jarai Z. et al.(2011)· Human Genetics

Genome-wide association study identifying rs17632542 (Ile179Thr) in KLK3 gene as a strong prostate cancer susceptibility variant (combined P = 1.9 × 10⁻³⁴, OR = 0.66) across 10,405 cases and 10,681 controls. The variant was also associated with PSA levels and molecular dynamics modeling suggested it could alter protein stability or affect RNA splicing of KLK3.

Traits studied:Gleason scorePSA levelProstate cancer
PubMedDOIMetascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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