rs2660

This is a variant in the OAS1 gene that changes a glycine to an arginine.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

poly(U)-specific endoribonuclease measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele A

OR 0.04

p 7.0e-18

N 47,745

Large GWAS

European

COVID-19

Pairo-Castineira E et al. “GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.” Nature 617(7962):764-768 (2023)

Allele A

OR 1.10

p 3.0e-15

N 1,779,771

Meta-analysisLarge GWAS

multi-ancestry

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ClinVar annotation

Benign★★★☆

4 submitters1 publication

OAS1-related disorder; not specified

View on ClinVar →

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Research that mentions this SNP (1)

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2′‐5′ oligoadenylate synthetase 1 polymorphism is associated with prostate cancer

AssociationN=304Sanjay Mandal et al.(2011)· Cancer

This case-control study of 304 samples (164 cancer, 140 control) found that the OAS1 rs2660 AA genotype was significantly associated with increased prostate cancer risk (OR=2.4, p=0.0006), while the GG genotype was protective (OR=0.066, p<0.0001), reducing risk by 92%. The association was consistent across both Caucasian and African American populations, with the AA genotype showing additive effects with age.

Traits studied:Prostate cancer

PubMed DOI Metascience Observatory

About OAS1

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cellular processes like cell growth and apoptosis. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection, including SARS-CoV-2, and diabetes mellitus, type 1. This gene is located in a cluster of related genes on chromosome 12. [provided by RefSeq, May 2022]