rs2664593

This case-control study investigated associations between genetic polymorphisms in lipoxygenase pathway genes (ALOX5, FLAP, ALOX12, ALOX15) and colorectal cancer risk across three US populations (colon cancer: 1424 cases/1780 controls; rectal cancer: 583 cases/775 controls; adenoma: 485 cases/578 controls). The ALOX5 VNTR variant was associated with significantly lower rectal cancer risk (OR>5/≥5 vs 5/5 = 0.42, p=0.01). Four SNPs (rs17239025, rs2073438, rs4796535, rs2619112) were associated with rectal cancer risk at p≤0.05. Genetic variability in FLAP and ALOX15 modified the protective effect of NSAID use against colorectal neoplasia, particularly for rectal cancer.

A candidate gene association study of 6,752 women from the Study of Osteoporotic Fractures examined 31 polymorphisms in 18 candidate osteoporosis genes for associations with fracture risk and bone mineral density. ALOX15_G48924T (rs7220870) T/T genotype was associated with 33% higher hip fracture risk (HR=1.33, 95% CI 1.00-1.77); PRL_T228C (rs7739889) C alleles reduced nonvertebral fracture risk by ~20%; BMP2_A125611G (rs235764) G/G showed 51% higher vertebral fracture risk (OR=1.51, 95% CI 1.03-2.23); and MMP2_C595T (rs243865) T allele carriers had reduced vertebral fracture risk. No significant associations were found with total hip BMD.