ALOX15
arachidonate 15-lipoxygenase
Summary
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
Known Variants58 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs11568131 | 17:4,534,608 | G/A | 3 prime UTR variant | — |
| rs916055 | 17:4,534,834 | A/C | — | — |
| rs190360172 | 17:4,534,943 | G/C | — | benign |
| rs764803400 | 17:4,534,965 | C/T | — | uncertain significance |
| rs755496566 | 17:4,534,974 | A/G | — | uncertain significance |
| rs2508013957 | 17:4,534,983 | T/C | — | uncertain significance |
| rs41432647 | 17:4,535,035 | G/A | — | benign |
| rs751640224 | 17:4,535,049 | T/C | — | uncertain significance |
| rs781764448 | 17:4,535,058 | T/C | — | uncertain significance |
| rs138472652 | 17:4,535,186 | T/C | — | likely benign |
| rs141604903 | 17:4,535,190 | G/A | — | likely benign |
| rs147458306 | 17:4,535,298 | C/T | — | benign |
| rs770448397 | 17:4,535,309 | G/A | — | uncertain significance |
| rs34210653 | 17:4,535,314 | G/A | missense variant | benign |
| rs2619112 | 17:4,535,385 | A/G | regulatory region variant | — |
| rs962046079 | 17:4,535,492 | G/A | — | uncertain significance |
| rs917942648 | 17:4,535,496 | C/T | — | uncertain significance |
| rs748459113 | 17:4,535,571 | G/A | — | uncertain significance |
| rs750193083 | 17:4,536,222 | C/T | — | uncertain significance |
| rs11568126 | 17:4,536,432 | T/C | — | benign |
| rs760167475 | 17:4,536,442 | G/A | — | uncertain significance |
| rs144526853 | 17:4,536,463 | G/A | — | uncertain significance |
| rs371901374 | 17:4,536,511 | G/A | — | uncertain significance |
| rs1249089898 | 17:4,536,558 | G/A | — | uncertain significance |
| rs138381552 | 17:4,536,582 | A/C | — | likely benign |
| rs149525246 | 17:4,536,747 | T/C | — | uncertain significance |
| rs763038338 | 17:4,536,774 | A/G | — | uncertain significance |
| rs752370680 | 17:4,536,777 | G/A | — | uncertain significance |
| rs372810070 | 17:4,539,067 | T/C | — | uncertain significance |
| rs2508029463 | 17:4,539,092 | T/C | — | uncertain significance |
| rs11568113 | 17:4,539,171 | G/T | — | benign |
| rs376786553 | 17:4,539,214 | G/A | — | uncertain significance |
| rs7217186 | 17:4,539,392 | C/G | — | — |
| rs199757246 | 17:4,540,475 | G/A | — | benign |
| rs760254381 | 17:4,540,499 | C/T | — | uncertain significance |
| rs780293609 | 17:4,540,525 | G/C | — | uncertain significance |
| rs527619134 | 17:4,540,553 | C/T | — | uncertain significance |
| rs2508038030 | 17:4,541,646 | C/T | — | uncertain significance |
| rs11568101 | 17:4,541,908 | C/T | — | benign |
| rs772679977 | 17:4,541,933 | A/G | — | uncertain significance |
| rs1292094969 | 17:4,542,193 | C/T | — | uncertain significance |
| rs762581638 | 17:4,542,216 | T/C | — | likely benign |
| rs113604586 | 17:4,542,349 | T/C | missense variant | — |
| rs11078528 | 17:4,542,717 | G/T | — | — |
| rs11568099 | 17:4,542,753 | G/C | — | benign |
| rs41439950 | 17:4,542,757 | C/A | — | uncertain significance |
| rs139214774 | 17:4,542,791 | C/T | — | uncertain significance |
| rs11568142 | 17:4,542,794 | C/G | — | likely benign |
| rs201844503 | 17:4,542,859 | C/T | — | uncertain significance |
| rs200209568 | 17:4,542,860 | G/A | — | uncertain significance |
| rs11568091 | 17:4,543,745 | G/A | — | — |
| rs752012098 | 17:4,544,569 | A/T | — | — |
| rs1911331259 | 17:4,544,825 | G/A | — | uncertain significance |
| rs752075488 | 17:4,544,835 | G/C | — | uncertain significance |
| rs147708465 | 17:4,544,865 | C/T | — | uncertain significance |
| rs2664593 | 17:4,545,132 | C/G | intron variant | — |
| rs7220870 | 17:4,545,218 | C/A | intron variant | — |
| rs11568070 | 17:4,545,238 | G/A | intron variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.