rs7217186
This variant is located in the ALOX15 gene.
▶Research that mentions this SNP (1)
▶Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han populationAssociationN=1,127Kai Zhang et al.(2010)· Heart and Vessels
A case-control study in 1,127 Chinese Han subjects (519 CAD patients, 608 controls) found that two ALOX15 polymorphisms, rs7217186:T>C and rs2619112:G>A, were significantly associated with coronary artery disease risk. In the adjusted model, rs7217186 C allele carriers showed OR=3.2 (p=0.009) and rs2619112 A allele carriers showed OR=3.5 (p=0.011) for CAD susceptibility.
About ALOX15
This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]
View all ALOX15 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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