rs2668639
This is a downstream gene variant variant in the LRRC37A gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
white matter integrity
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele C
OR 0.09
p 3.0e-15
N 20,860
Major Consortium StudyLarge GWAS
European
brain age measurement
Zhao X et al. “Regulatory Genomic Circuitry of Brain Age by Integrative Functional Genomic Analyses.” Genomics, Proteomics & Bioinformatics 23(5) (2025)
Allele T
OR 0.21
p 2.0e-14
N 35,702
Large GWAS
European
encounter with health service
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.06
p 1.0e-11
N 620,623
Major Consortium StudyLarge GWAS
multi-ancestry
About LRRC37A
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all LRRC37A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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