rs2675

This is a 3 prime utr variant variant in the ITGB5 gene.

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Research that mentions this SNP (1)

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Genetic variants in the integrin gene predicted microRNA-binding sites were associated with the risk of prostate cancer
ReviewJiaming Liu et al.(2014)· Molecular Carcinogenesis

This review examines how non-coding RNAs (miRNAs and lncRNAs) regulate integrin gene expression in cancer. Several SNPs in integrin genes affect cancer risk through disruption of miRNA binding sites: ITGB3 rs3809865 associates with oral squamous cell carcinoma risk, ITGB4 rs743554 with breast cancer progression, ITGB5 rs2675 with bladder cancer, ITGAV rs11902171 with prostate cancer risk, and ITGA2 rs6898333 and rs6880055 with prostate cancer risk.

Traits studied:Bladder cancerBreast cancerCancer metastasisCervical cancerColorectal cancerCutaneous melanomaGastric cancerGliomaHepatocellular carcinomaLung cancerNasopharyngeal carcinomaNon-small cell lung cancerOral squamous cell carcinomaOsteosarcomaOvarian cancerPancreatic cancerPapillary thyroid carcinomaProstate cancerRhabdomyosarcoma
PubMedDOIMetascience Observatory

About ITGB5

This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signaling. The alphav beta5 integrin is involved in adhesion to vitronectin. [provided by RefSeq, Aug 2017]

View all ITGB5 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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