rs2732703
This is a intron variant variant in the LRRC37A gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Alzheimer disease
▶Research that mentions this SNP (1)
▶An association study of common variation at the MAPT locus with late‐onset Alzheimer's diseaseAssociationN=17,996Richard Abraham et al.(2009)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This case-control association study in 4,124 Spanish Alzheimer's disease cases and 3,290 controls demonstrates that the MAPT H1 haplotype, tagged by rs1800547, is a risk factor for AD (OR=1.12, p=0.0025) primarily in APOE ε4 non-carriers (OR=1.15, p=0.0022). Pooled analysis of two Spanish datasets totaling 17,996 individuals shows strongest AD risk in the oldest APOE ε4 non-carriers, suggesting MAPT H1 variants may track a genuine risk allele through a tau-dependent pathway less dependent on amyloid burden.
About LRRC37A
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all LRRC37A variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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