rs2785990

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GWAS Catalog Trait Associations (7)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

pulse pressure measurement

Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele T
OR 0.15
p 3.0e-20
N 1,164,961
Meta-analysisLarge GWAS
European

Umbilical hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele C
OR 1.21
p 2.0e-17
N 275,546
Major Consortium StudyLarge GWAS
European

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele C
OR 0.01
p 1.0e-16
N 1,122,049
Large GWAS
European

BMI-adjusted fasting blood insulin measurement

Downie CG et al. “Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study.” Diabetologia 65(3):477-489 (2022)
Allele T
OR 0.05
p 3.0e-10
N 48,395
Large GWAS
multi-ancestry

systolic blood pressure

Surendran P et al. “Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.” Nature Genetics 52(12):1314-1332 (2020)
Allele T
OR 0.15
p 6.0e-10
N 1,164,961
Meta-analysisLarge GWAS
European

Inguinal hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)
Allele C
OR 1.07
p 1.0e-9
N 275,546
Major Consortium StudyLarge GWAS
European

triglyceride measurement

Liu DJ et al. “Exome-wide association study of plasma lipids in >300,000 individuals.” Nature Genetics 49(12):1758-1766 (2017)
Allele T
OR —
β 0.018
p 3.0e-8
N 237,050
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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