rs28361101
This is a regulatory region variant variant in the CTNNAL1 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
white matter integrity, age at assessment
Traylor M et al. “The BS variant of C4 protects against age-related loss of white matter microstructural integrity.” Brain : a Journal of Neurology 145(1):295-304 (2022)
Allele C
OR —
p 8.0e-10
N 31,128
Large GWAS
European
white matter integrity
Smith SM et al. “An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank.” Nature Neuroscience 24(5):737-745 (2021)
Allele C
OR 0.17
p 3.0e-8
N 20,860
Major Consortium StudyLarge GWAS
European
About CTNNAL1
Predicted to enable actin filament binding activity and cadherin binding activity. Acts upstream of or within Rho protein signal transduction. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
View all CTNNAL1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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