rs28435578

This variant is located in the LOC107986195 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

hypothyroidism

White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)

Allele C

OR 0.11

p 1.0e-121

N 1,786,062

Large GWAS

European

Rand SA et al. “Genome-wide association study and polygenic risk prediction of hypothyroidism.” Nature Genetics 57(12):3007-3015 (2025)

Allele C

OR 0.13

p 6.0e-89

N 1,178,661

Large GWAS

European

Thyroid stimulating hormone level

Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)

Allele C

OR 0.19

p 1.0e-94

N 153,950

Large GWAS

East Asian

Wei Y et al. “Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies.” Nature Communications 15(1):8004 (2024)

Allele C

OR 0.14

p 3.0e-30

N 67,471

Large GWAS

East Asian

Taylor PN et al. “Whole-genome sequence-based analysis of thyroid function.” Nature Communications 6:5681 (2015)

Allele C

OR 0.17

p 5.0e-32

N 16,335

Large GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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