rs28469095
This is a protein-altering variant in the NKPD1 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Alzheimer disease, family history of Alzheimer’s disease
Jansen IE et al. “Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.” Nature Genetics 51(3):404-413 (2019)
Allele C
OR 12.96
p 2.0e-38
N 455,258
Meta-analysisLarge GWAS
European
Willett JDS et al. “Identification of 16 novel Alzheimer's disease loci using multi-ancestry meta-analyses.” Alzheimer's & Dementia : the Journal of the Alzheimer's Association 21(2):e14592 (2025)
Allele C
OR —
p 1.0e-11
N 404,467
Large GWAS
multi-ancestry
Alzheimer disease
Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele C
OR 0.04
p 2.0e-32
N 640,258
Large GWAS
European
Alzheimer's disease biomarker measurement
Koskeridis F et al. “Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.” Nature Communications 15(1):9827 (2024)
Allele C
OR 0.03
p 4.0e-23
N 568,836
Large GWAS
European
About NKPD1
Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
View all NKPD1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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