rs28712821

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GWAS Catalog Trait Associations (11)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

alcohol consumption quality

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele A
OR 0.02
p 2.0e-180
N 2,965,643
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified
Brazel DM et al. “Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.” Biological Psychiatry 85(11):946-955 (2019)
Allele A
OR 0.04
p 2.0e-42
N 357,854
Meta-analysisLarge GWAS
European
Clarke TK et al. “Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117).” Molecular Psychiatry 22(10):1376-1384 (2017)
Allele A
OR 0.03
p 7.0e-11
N 112,117
Major Consortium StudyLarge GWAS
European

serum gamma-glutamyl transferase measurement

Ghouse J et al. “Integrative common and rare variant analyses provide insights into the genetic architecture of liver cirrhosis.” Nature Genetics 56(5):827-837 (2024)
Allele G
OR 0.01
p 3.0e-27
N 875,069
Large GWAS
European
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele G
OR 0.01
p 2.0e-19
N 928,679
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele G
OR 0.02
p 1.0e-17
N 477,575
Large GWAS
multi-ancestry

taste liking measurement

May-Wilson S et al. “Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.” Nature Communications 13(1):2743 (2022)
Allele A
OR 0.04
p 4.0e-25
N 159,554
Large GWAS
European

blood urea nitrogen amount

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.02
p 2.0e-20
N 492,819
Large GWAS
multi-ancestry

diet measurement

Merino J et al. “Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits.” Nature Human Behaviour 6(1):155-163 (2022)
Allele A
OR —
p 3.0e-19
N 282,271
Large GWAS
European

protein intake measurement

Merino J et al. “Genetic analysis of dietary intake identifies new loci and functional links with metabolic traits.” Nature Human Behaviour 6(1):155-163 (2022)
Allele T
OR 0.19
p 4.0e-12
N 282,271
Large GWAS
European

heart failure

Lee DSM et al. “Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.” Nature Genetics 57(4):829-838 (2025)
Allele A
OR 0.02
p 4.0e-9
N 2,358,556
Large GWAS
multi-ancestry

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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