rs2897075

This variant is located in the ZKSCAN1 gene.

▶

GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

idiopathic pulmonary fibrosis

Allen RJ et al. “Genome-wide association study across five cohorts identifies five novel loci associated with idiopathic pulmonary fibrosis.” Thorax 77(8):829-833 (2022)
Allele T
OR 1.30
p 2.0e-21
N 24,589
Large GWAS
European
Allen RJ et al. “Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.” American Journal of Respiratory and Critical Care Medicine 201(5):564-574 (2020)
Allele T
OR 1.30
p 3.0e-14
N 11,259
Large GWAS
European

chronic obstructive pulmonary disease

Sakornsakolpat P et al. “Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.” Nature Genetics 51(3):494-505 (2019)
Allele C
OR 1.07
p 7.0e-10
N 257,811
Large GWAS
European, East Asian, African American or Afro-Caribbean, Hispanic or Latin American, NR

COVID-19

Pairo-Castineira E et al. “GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19.” Nature 617(7962):764-768 (2023)
Allele T
OR 1.10
p 6.0e-9
N 2,974,917
Meta-analysisLarge GWAS
multi-ancestry
Diz-de Almeida S et al. “Novel risk loci for COVID-19 hospitalization among admixed American populations.” Elife 13 (2024)
Allele T
OR 0.05
p 6.0e-9
N 73,303
Large GWAS
multi-ancestry

About ZKSCAN1

This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. [provided by RefSeq, Oct 2016]

View all ZKSCAN1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…