rs28971325
This is a regulatory region variant variant in the WNT7B gene.
▶GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (7)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Fasciitis
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.19
p 2.0e-102
N 426,643
Major Consortium StudyLarge GWAS
European
frozen shoulder
Green HD et al. “A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor.” Plos Genetics 17(6):e1009577 (2021)
Allele A
OR 1.21
p 8.0e-37
N 627,998
Large GWAS
European
Dupuytren Contracture
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.99
p 1.0e-34
N 59,625
Major Consortium StudyLarge GWAS
Hispanic or Latin American
contracture
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.37
p 3.0e-29
N 446,952
Major Consortium StudyLarge GWAS
European
body height
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.01
p 6.0e-14
N 394,642
Large GWAS
European
Schoeler T et al. “Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.” Nature Communications 16(1):4524 (2025)
Allele A
OR 0.01
p 3.0e-12
N 405,540
Large GWAS
European
male reproductive system disease
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.13
p 4.0e-11
N 410,434
Major Consortium StudyLarge GWAS
European
Peyronie disease
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele G
OR 0.30
p 2.0e-19
N 416,103
Major Consortium StudyLarge GWAS
European
About WNT7B
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
View all WNT7B variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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