rs2928167

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Thyroid stimulating hormone level

Williams AT et al. “Genome-wide association study of thyroid-stimulating hormone highlights new genes, pathways and associations with thyroid disease.” Nature Communications 14(1):6713 (2023)
Allele A
OR 0.13
p 1.0e-279
N 247,107
Large GWAS
multi-ancestry
Zhou W et al. “GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer.” Nature Communications 11(1):3981 (2020)
Allele A
OR 0.14
p 2.0e-85
N 119,715
Large GWAS
European
Wei Y et al. “Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies.” Nature Communications 15(1):8004 (2024)
Allele A
OR 0.15
p 2.0e-36
N 67,471
Large GWAS
East Asian
Taylor PN et al. “Whole-genome sequence-based analysis of thyroid function.” Nature Communications 6:5681 (2015)
Allele A
OR 0.14
p 6.0e-14
N 16,335
Large GWAS
European

hypothyroidism

Wei Y et al. “Genome-wide association studies of thyroid-related hormones, dysfunction, and autoimmunity among 85,421 Chinese pregnancies.” Nature Communications 15(1):8004 (2024)
Allele A
OR 1.33
p 2.0e-10
N 73,050
Large GWAS
East Asian
White SL et al. “Global multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.” Nature Genetics 58(2):307-316 (2026)
Allele A
OR 0.10
p 3.0e-8
N 119,134
Large GWAS
Hispanic or Latin American

erythrocyte count

Astle WJ et al. “The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.” Cell 167(5):1415-1429.e19 (2016)
Allele G
OR 0.03
p 7.0e-10
N 172,952
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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