rs2943650

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GWAS Catalog Trait Associations (43)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

type 2 diabetes mellitus

Vujkovic M et al. “Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.” Nature Genetics 52(7):680-691 (2020)

Allele C

OR 0.08

p 2.0e-81

N 1,407,282

Meta-analysisLarge GWAS

multi-ancestry

triglycerides to phosphoglycerides ratio

Yuan F et al. “Blood metabolic biomarkers and colorectal cancer risk: results from large prospective cohort and Mendelian randomisation analyses.” British Journal of Cancer 133(1):94-103 (2025)

Allele C

OR 0.05

p 2.0e-52

N 199,732

Large GWAS

European

low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.05

p 9.0e-34

N 115,082

Large GWAS

European

triglyceride measurement, phospholipid level

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.05

p 7.0e-33

N 115,006

Large GWAS

European

cholesteryl esters:total lipids ratio, blood VLDL cholesterol amount

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.05

p 2.0e-32

N 115,082

Large GWAS

European

cholesterol:total lipids ratio, blood VLDL cholesterol amount

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.05

p 2.0e-31

N 115,082

Large GWAS

European

triglycerides:total lipids ratio, intermediate density lipoprotein measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.05

p 5.0e-30

N 115,082

Large GWAS

European

cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.05

p 3.0e-29

N 115,082

Large GWAS

European

cholesteryl ester measurement, high density lipoprotein cholesterol measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.04

p 2.0e-27

N 115,082

Large GWAS

European

phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement

Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)

Allele C

OR 0.04

p 5.0e-27

N 115,082

Large GWAS

European

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Research that mentions this SNP (1)

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Genetic variation at the CELF1 (CUGBP, elav‐like family member 1 gene) locus is genome‐wide associated with Alzheimer's disease and obesity

ReviewAnke Hinney et al.(2014)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

This literature review examines the influence of genetic polymorphisms on obesity development and adaptive responses to physical activity, focusing on five candidate genes: COMT (rs4680, Val158Met), DRD2 (rs1800497 Taq1A and rs1799732), FABP2 (rs1799883, Ala54Thr), FTO (rs9939609, A/T), and UCP1 (rs1800592, A-3826G). The review synthesizes molecular mechanisms, phenotypic associations, and implications for human health and training adaptations, noting that physical activity reduces the FTO genetic effect on obesity risk by 30-80% and that various polymorphisms show differential impacts on body composition and metabolic responses to exercise.

Traits studied:Adipose tissue distributionAthletic performanceBody Mass Index (BMI)Body compositionExercise adaptationFat massMuscle massObesityPhysical activity responseWeight loss

PubMed DOI Metascience Observatory

This variant is in our database but has no known associations or PRS memberships yet.

rs2943650

GWAS Catalog Trait Associations (43)

type 2 diabetes mellitus

triglycerides to phosphoglycerides ratio

low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

triglyceride measurement, phospholipid level

cholesteryl esters:total lipids ratio, blood VLDL cholesterol amount

cholesterol:total lipids ratio, blood VLDL cholesterol amount

triglycerides:total lipids ratio, intermediate density lipoprotein measurement

cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement

cholesteryl ester measurement, high density lipoprotein cholesterol measurement

phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement

Research that mentions this SNP (1)

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