rs2943652
▶GWAS Catalog Trait Associations (21)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (21)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
body fat percentage, high density lipoprotein cholesterol measurement
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele C
OR —
p 7.0e-32
N 287,833
Large GWAS
multi-ancestry
triglyceride measurement, body fat percentage
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele C
OR —
p 4.0e-27
N 278,577
Large GWAS
multi-ancestry
body fat percentage, type 2 diabetes mellitus
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele C
OR —
p 4.0e-20
N 225,264
Large GWAS
multi-ancestry
body mass index, high density lipoprotein cholesterol measurement
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele C
OR —
p 7.0e-20
N 526,391
Large GWAS
multi-ancestry
serum alanine aminotransferase amount
Vujkovic M et al. “A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.” Nature Genetics 54(6):761-771 (2022)
Allele C
OR 0.06
p 1.0e-19
N 218,595
Large GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.02
p 4.0e-14
N 583,801
Major Consortium StudyLarge GWAS
multi-ancestry
body fat percentage, blood insulin amount
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele C
OR —
p 2.0e-18
N 152,466
Large GWAS
multi-ancestry
triglyceride measurement, blood VLDL cholesterol amount
Richardson TG et al. “Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisation.” Plos Biology 20(2):e3001547 (2022)
Allele C
OR 0.03
p 1.0e-16
N 115,082
Large GWAS
European
triglyceride measurement, body mass index
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele C
OR —
p 1.0e-16
N 517,085
Large GWAS
multi-ancestry
hypertension, Antihypertensive use measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.04
p 2.0e-13
N 315,668
Major Consortium StudyLarge GWAS
European
body mass index, type 2 diabetes mellitus
Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)
Allele C
OR —
p 1.0e-12
N 449,443
Large GWAS
multi-ancestry
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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