rs2955617

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

free cholesterol in HDL measurement

Zoodsma M et al. “A genetic map of human metabolism across the allele frequency spectrum.” Nature Genetics 57(10):2445-2455 (2025)

Allele A

OR 0.01

p 1.0e-13

N 450,015

Large GWAS

multi-ancestry

BMI-adjusted waist circumference

Christakoudi S et al. “GWAS of allometric body-shape indices in UK Biobank identifies loci suggesting associations with morphogenesis, organogenesis, adrenal cell renewal and cancer.” Scientific Reports 11(1):10688 (2021)

Allele C

OR 0.02

p 5.0e-11

N 219,872

Major Consortium StudyLarge GWAS

European

body fat percentage, high density lipoprotein cholesterol measurement

Huang LO et al. “Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities.” Nature Metabolism 3(2):228-243 (2021)

Allele A

OR —

p 5.0e-9

N 287,833

Large GWAS

multi-ancestry

gluteofemoral adipose tissue measurement

Agrawal S et al. “Inherited basis of visceral, abdominal subcutaneous and gluteofemoral fat depots.” Nature Communications 13(1):3771 (2022)

Allele C

OR 0.04

p 1.0e-8

N 37,641

Large GWAS

European, East Asian, South Asian, African unspecified, NR

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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