rs2987763
This is a upstream gene variant variant in the PGLYRP3 gene.
▶Research that mentions this SNP (1)
▶Peptidoglycan recognition protein genes and risk of Parkinson's diseaseAssociationN=990Goldman SM et al.(2014)· Movement Disorders
Case-control genetic association study of 990 participants (480 cases, 510 controls) from two independent cohorts testing 30 SNPs across four PGLYRP genes (encoding peptidoglycan recognition proteins) for association with Parkinson's disease risk. Variants in PGLYRP2 (rs3813135, rs733731, rs892145), PGLYRP3 (rs2987763), and PGLYRP4 (rs10888557, rs12063091, rs3006440, rs3006448, rs3006458, rs3014864) were significantly associated with PD risk. The strongest association was PGLYRP4 rs10888557 (5'UTR), where the CC genotype showed OR 0.15 (95% CI 0.04-0.6) compared to GG reference (P-trend = 0.0004). Most minor alleles were associated with reduced PD risk, consistent with a role for gut microbiota and immune response in disease pathogenesis.
About PGLYRP3
This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
View all PGLYRP3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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