rs3025343

This is a coding sequence variant variant.

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GWAS Catalog Trait Associations (6)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

tobacco smoke exposure measurement

Brazel DM et al. “Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.” Biological Psychiatry 85(11):946-955 (2019)
Allele A
OR 0.05
p 2.0e-21
N 150,993
Meta-analysisLarge GWAS
European

smoking initiation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele A
OR 0.01
p 3.0e-18
N 3,382,012
Large GWAS
European, East Asian, Hispanic or Latin American, African unspecified

body mass index

Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele G
OR 0.01
p 2.0e-12
N 1,122,049
Large GWAS
European

smoking cessation

Erzurumluoglu AM et al. “Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.” Molecular Psychiatry 25(10):2392-2409 (2020)
Allele A
OR 0.04
p 4.0e-12
N 121,543
Meta-analysisLarge GWAS
multi-ancestry

cigarettes per day measurement

Brazel DM et al. “Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.” Biological Psychiatry 85(11):946-955 (2019)
Allele A
OR 0.04
p 6.0e-11
N 153,918
Meta-analysisLarge GWAS
European

smoking behavior

“Genome-wide meta-analyses identify multiple loci associated with smoking behavior.” Nature Genetics 42(5):441-7 (2010)
Allele G
OR 1.12
p 4.0e-8
N 74,035
Large GWAS
European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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