rs3132535

This variant is located in the CCHCR1 gene.

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GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

multiple myeloma

Went M et al. “Deciphering the genetics and mechanisms of predisposition to multiple myeloma.” Nature Communications 15(1):6644 (2024)
Allele A
OR 1.19
p 2.0e-22
N 377,127
Large GWAS
European
Mitchell JS et al. “Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.” Nature Communications 7:12050 (2016)
Allele A
OR 1.20
p 3.0e-17
N 241,704
Large GWAS
European

sex hormone-binding globulin measurement

Harrison S et al. “Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank.” Science Advances 7(31) (2021)
Allele G
OR 1.03
p 1.0e-8
N 104,632
Major Consortium StudyLarge GWAS
European

About CCHCR1

This gene encodes a protein with five coiled-coil alpha-helical rod domains that is thought to act as a regulator of mRNA metabolism through its interaction with mRNA-decapping protein 4. It localizes to P-bodies, the site of mRNA metabolism, with an N-terminus that is required for this subcellular localization, suggesting it is a P-body component. Naturally occurring mutations in this gene are associated with psoriasis. [provided by RefSeq, May 2017]

View all CCHCR1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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