rs3135394

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Sjogren syndrome

Lessard CJ et al. “Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.” Nature Genetics 45(11):1284-92 (2013)

Allele G

OR 3.52

p 5.0e-113

N 2,370

Large GWAS

European

systemic lupus erythematosus

Gateva V et al. “A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.” Nature Genetics 41(11):1228-33 (2009)

Allele G

OR 1.98

p 2.0e-60

N 9,169

Large GWAS

European

sarcoidosis

Rivera NV et al. “High-Density Genetic Mapping Identifies New Susceptibility Variants in Sarcoidosis Phenotypes and Shows Genomic-driven Phenotypic Differences.” American Journal of Respiratory and Critical Care Medicine 193(9):1008-22 (2016)

Allele G

OR —

p 3.0e-33

N 1,048

Large GWAS

European

Inguinal hernia

Wei J et al. “Identification of fifty-seven novel loci for abdominal wall hernia development and their biological and clinical implications: results from the UK Biobank.” Hernia : the Journal of Hernias and Abdominal Wall Surgery 26(1):335-348 (2022)

Allele A

OR 1.10

p 5.0e-8

N 275,546

Major Consortium StudyLarge GWAS

European

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

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