rs314276

This variant is located in the LIN28B gene.

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GWAS Catalog Trait Associations (3)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

body height

Yengo L et al. “A saturated map of common genetic variants associated with human height.” Nature 610(7933):704-712 (2022)
Allele A
OR 0.03
p 8.0e-22
N 293,593
Large GWAS
African unspecified
Chiou JS et al. “Your height affects your health: genetic determinants and health-related outcomes in Taiwan.” Bmc Medicine 20(1):250 (2022)
Allele A
OR 0.04
p 3.0e-11
N 67,452
Large GWAS
East Asian
Tachmazidou I et al. “Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.” American Journal of Human Genetics 100(6):865-884 (2017)
Allele A
OR 0.06
p 2.0e-14
N 57,129
Large GWAS
European

age at menarche

Ong KK et al. “Genetic variation in LIN28B is associated with the timing of puberty.” Nature Genetics 41(6):729-33 (2009)
Allele C
OR 0.14
p 4.0e-16
N 4,714
Large GWAS
European

puberty onset measurement

Cousminer DL et al. “Genome-wide association study of sexual maturation in males and females highlights a role for body mass and menarche loci in male puberty.” Human Molecular Genetics 23(16):4452-64 (2014)
Allele C
OR 0.08
p 2.0e-8
N 9,916
Large GWAS
European

About LIN28B

The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

View all LIN28B variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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