LIN28B
lin-28 RNA binding posttranscriptional regulator B
Summary
The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]
Known Variants35 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs2095812 | 6:105,383,978 | C/G | downstream gene variant | — |
| rs12207399 | 6:105,385,612 | G/A | intron variant | — |
| rs7766336 | 6:105,388,405 | T/G | regulatory region variant | — |
| rs12528131 | 6:105,389,104 | A/C | — | — |
| rs1475120 | 6:105,389,953 | G/A | regulatory region variant | — |
| rs314265 | 6:105,390,567 | C/T | upstream gene variant | — |
| rs314264 | 6:105,392,382 | A/C | upstream gene variant | — |
| rs314263 | 6:105,392,745 | C/T | upstream gene variant | — |
| rs314281 | 6:105,400,605 | T/G | — | — |
| rs314280 | 6:105,400,837 | A/G | regulatory region variant | — |
| rs314279 | 6:105,402,083 | C/G | — | — |
| rs12194974 | 6:105,404,198 | G/A | regulatory region variant | — |
| rs56339318 | 6:105,404,562 | A/C | regulatory region variant | — |
| rs386352325 | 6:105,405,130 | C/A | — | uncertain significance |
| rs17065417 | 6:105,406,274 | A/C | regulatory region variant | — |
| rs314277 | 6:105,407,662 | A/T | — | — |
| rs314276 | 6:105,407,999 | A/G | — | — |
| rs314268 | 6:105,417,978 | G/T | — | — |
| rs546222705 | 6:105,437,470 | T/G | — | — |
| rs314283 | 6:105,439,336 | T/C | intron variant | — |
| rs364663 | 6:105,443,189 | T/A | intron variant | — |
| rs369065 | 6:105,444,058 | C/T | regulatory region variant | — |
| rs314261 | 6:105,453,417 | A/C | intron variant | — |
| rs314273 | 6:105,461,882 | T/C | — | — |
| rs160593 | 6:105,466,332 | G/T | — | — |
| rs221618 | 6:105,472,320 | G/A | intron variant | — |
| rs186680543 | 6:105,474,231 | C/T | — | uncertain significance |
| rs770962930 | 6:105,474,316 | C/T | — | benign |
| rs6902142 | 6:105,479,558 | A/G | intron variant | — |
| rs35965375 | 6:105,511,521 | G/A | — | — |
| rs1255551412 | 6:105,526,389 | G/A | — | uncertain significance |
| rs201716597 | 6:105,526,426 | C/T | — | likely benign |
| rs1562116813 | 6:105,526,491 | G/A | — | uncertain significance |
| rs150452636 | 6:105,526,519 | C/T | — | uncertain significance |
| rs867034956 | 6:105,526,554 | C/T | — | likely benign |
Gene information from NCBI Gene. Variant classifications from ClinVar.