rs31489
This is a intron variant variant in the CLPTM1L gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
lung adenocarcinoma
Landi MT et al. “A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.” American Journal of Human Genetics 85(5):679-91 (2009)
Allele C
OR 1.12
p 2.0e-10
N 11,587
Large GWAS
European
About CLPTM1L
The protein encoded by this gene is a membrane protein whose overexpression in cisplatin-sensitive cells causes apoptosis. Polymorphisms in this gene have been reported to increase susceptibility to several cancers, including lung, pancreatic, and breast cancers. [provided by RefSeq, Nov 2015]
View all CLPTM1L variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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