rs332034
This variant is located in the MFHAS1 gene.
▶Research that mentions this SNP (1)
▶Does parental expressed emotion moderate genetic effects in ADHD? an exploration using a genome wide association scanAssociationN=909Edmund J.S. Sonuga‐Barke et al.(2008)· American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
This genome-wide association study examined whether parental expressed emotion moderates genetic effects on ADHD symptoms and conduct disorder in 909 family trios (600,000 SNPs genotyped). No gene-by-environment interactions reached genome-wide significance. Nominal effects were observed with 36 uncorrected interaction P-values <10⁻⁵, implicating both novel genes and candidate genes. SNPs in SLC1A1 and NRG3 emerged as candidate genes for follow-up, though the authors emphasize these findings are preliminary and require replication.
About MFHAS1
Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008]
View all MFHAS1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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