MFHAS1

multifunctional ROCO family signaling regulator 1

Summary

Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008]

Known Variants102 total

rsidPosition (GRCh37)AllelesClassClinVar
rs126823528:8,646,246T/A——
rs78329688:8,652,889G/C——
rs24090918:8,654,057G/C——
rs7569820028:8,654,881C/T—uncertain significance
rs38278128:8,654,898C/T—benign
rs24861579268:8,654,908G/A—uncertain significance
rs24861580038:8,654,936C/T—uncertain significance
rs12086761398:8,654,943G/C—uncertain significance
rs69889398:8,666,916C/A——
rs603151348:8,670,599A/Gintron variant—
rs590460598:8,670,736C/Aintron variant—
rs48403678:8,690,911G/Aintron variant—
rs3320348:8,717,007T/A——
rs101089548:8,722,378C/Tintron variant—
rs3320378:8,722,675C/A——
rs1488542168:8,747,646C/T—uncertain significance
rs10518023348:8,747,730C/G—uncertain significance
rs3737489258:8,747,739C/T—uncertain significance
rs1144342398:8,747,797A/G—likely benign
rs7771384798:8,747,845G/C—uncertain significance
rs1442230268:8,747,926C/A—uncertain significance
rs759237338:8,748,032G/C—likely benign
rs7546438488:8,748,051G/C—uncertain significance
rs1465022538:8,748,058C/T—likely benign
rs15632236748:8,748,064T/A—uncertain significance
rs7688881298:8,748,074C/T—uncertain significance
rs7732827578:8,748,090T/A—uncertain significance
rs3726241838:8,748,132C/A—uncertain significance
rs10430826718:8,748,182C/G—uncertain significance
rs18099679598:8,748,185T/A—uncertain significance
rs24863432138:8,748,206T/C—uncertain significance
rs24863432608:8,748,216G/A—uncertain significance
rs7754305278:8,748,224G/A—uncertain significance
rs5504244188:8,748,227C/A—uncertain significance
rs1448865838:8,748,263G/A—likely benign
rs9132347758:8,748,269G/A—uncertain significance
rs13214924688:8,748,337A/C—uncertain significance
rs7550068538:8,748,377G/A—uncertain significance
rs7466863738:8,748,383T/C—uncertain significance
rs359719778:8,748,403G/A—benign
rs1999966498:8,748,459G/C—uncertain significance
rs7737761008:8,748,465T/C—uncertain significance
rs1399563538:8,748,603G/A—uncertain significance
rs5385077148:8,748,608T/C—uncertain significance
rs5715440418:8,748,637T/G—likely benign
rs18100048088:8,748,647T/C—uncertain significance
rs7641924228:8,748,651C/G—uncertain significance
rs18100082998:8,748,699C/A—uncertain significance
rs2013724538:8,748,700G/C—likely benign
rs3753166228:8,748,758C/G—uncertain significance
rs3757890708:8,748,834C/T—uncertain significance
rs3688222768:8,748,840C/T—uncertain significance
rs1418361748:8,748,877G/C—uncertain significance
rs1382675338:8,748,988C/T—likely benign
rs7600324588:8,748,999C/G—uncertain significance
rs7676890638:8,749,019C/G—uncertain significance
rs7690063328:8,749,068C/T—uncertain significance
rs1462862908:8,749,232C/T—uncertain significance
rs7614924538:8,749,273C/A—likely benign
rs18100541288:8,749,284G/A—uncertain significance
rs13301955338:8,749,317T/C—uncertain significance
rs12696883508:8,749,423G/A—likely benign
rs7549441138:8,749,448T/C—uncertain significance
rs1456592668:8,749,471C/G—likely benign
rs7646376188:8,749,481T/C—uncertain significance
rs3759925418:8,749,555G/A—likely benign
rs5392485338:8,749,559G/C—uncertain significance
rs1175025798:8,749,642G/A—likely benign
rs3771414438:8,749,695G/C—uncertain significance
rs37481418:8,749,729G/C—benign
rs24863532108:8,749,751T/C—uncertain significance
rs7578458558:8,749,788C/T—uncertain significance
rs18100945018:8,749,839C/G—uncertain significance
rs1505572788:8,749,847G/C—uncertain significance
rs1405442528:8,749,895G/A—uncertain significance
rs3745746518:8,749,936C/T—likely benign
rs350365398:8,749,990G/A—benign
rs7639533118:8,749,995G/T—uncertain significance
rs7698916278:8,750,036G/A—uncertain significance
rs24863556848:8,750,127G/C—uncertain significance
rs7563950068:8,750,172C/T—uncertain significance
rs7550339858:8,750,195G/C—uncertain significance
rs21169583098:8,750,198G/C—uncertain significance
rs7707598268:8,750,218G/A—likely benign
rs24863564008:8,750,240C/G—uncertain significance
rs18101239268:8,750,243A/C—uncertain significance
rs3765207708:8,750,244G/C—uncertain significance
rs1412785098:8,750,245C/T—benign
rs21169585378:8,750,246T/G—uncertain significance
rs7678589878:8,750,253C/G—uncertain significance
rs7508270298:8,750,255G/C—uncertain significance
rs9026559658:8,750,270G/C—uncertain significance
rs1457972708:8,750,330T/C—uncertain significance
rs1155976558:8,750,333G/C—benign
rs7653289308:8,750,351T/C—uncertain significance
rs7769008288:8,750,406G/C—uncertain significance
rs7630625278:8,750,411G/T—uncertain significance
rs3678891108:8,750,434G/A—likely benign
rs9729815388:8,750,439C/A—uncertain significance
rs5345160128:8,750,465G/A—uncertain significance

Showing 100 of 102 variants. Use the SNP search for the full list.

Gene information from NCBI Gene. Variant classifications from ClinVar.