rs12682352

This variant is located in the MFHAS1 gene.

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GWAS Catalog Trait Associations (4)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

brain attribute

van der Meer D et al. “The genetic architecture of human cortical folding.” Science Advances 7(51):eabj9446 (2021)
Allele C
OR 15.25
p 2.0e-52
N 33,748
Large GWAS
European

neuroticism measurement

Luciano M et al. “Association analysis in over 329,000 individuals identifies 116 independent variants influencing neuroticism.” Nature Genetics 50(1):6-11 (2018)
Allele C
OR 0.06
p 1.0e-24
N 329,821
Large GWAS
European
Smith DJ et al. “Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci.” Molecular Psychiatry 21(6):749-57 (2016)
Allele C
OR 0.12
p 2.0e-15
N 106,716
Large GWAS
European

body mass index

Harris BHL et al. “New role of fat-free mass in cancer risk linked with genetic predisposition.” Scientific Reports 14(1):7270 (2024)
Allele C
OR 0.02
p 3.0e-14
N 342,566
Large GWAS
European

taste liking measurement

May-Wilson S et al. “Large-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits.” Nature Communications 13(1):2743 (2022)
Allele C
OR 0.09
p 3.0e-15
N 158,684
Large GWAS
European

About MFHAS1

Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. [provided by RefSeq, Jul 2008]

View all MFHAS1 variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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