rs34372695
This is a downstream gene variant variant in the RAB25 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
Parkinson disease
Nalls MA et al. “Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.” Lancet (london, England) 377(9766):641-9 (2011)
Allele T
OR 1.47
p 4.0e-12
N 17,352
Meta-analysisLarge GWAS
multi-ancestry
Smeland OB et al. “Genome-wide Association Analysis of Parkinson's Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci.” Biological Psychiatry 89(3):227-235 (2021)
Allele T
OR 0.32
p 4.0e-12
N 417,508
Large GWAS
European
About RAB25
The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
View all RAB25 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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