rs34684276
This is a intron variant variant in the HYKK gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
nicotine dependence
Hancock DB et al. “Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.” Translational Psychiatry 5(10):e651 (2015)
Allele A
OR —
β 0.067
p 4.0e-17
N 17,074
Meta-analysisLarge GWAS
European
FEV/FVC ratio, response to bronchodilator
Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)
Allele A
OR —
β 0.017
p 8.0e-13
N 13,532
Large GWAS
multi-ancestry
forced expiratory volume, response to bronchodilator
Lutz SM et al. “A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.” Bmc Genetics 16:138 (2015)
Allele A
OR —
β 0.077
p 2.0e-11
N 13,532
Large GWAS
multi-ancestry
About HYKK
Enables hydroxylysine kinase activity. Predicted to be involved in lysine catabolic process. Predicted to be located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
View all HYKK variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…