Trait
SNPs associated with Nicotine Dependence
35 genetic variants across 12 genes have been associated with Nicotine Dependence in published research. Key genes include CACNA2D3, CHRNA3, CHRNA4.
Associated variants35 total
| rsid | Gene | Effect | Evidence |
|---|---|---|---|
| rs34684276 | HYKK | GWAS association (p=4.0e-17) | Meta-analysis |
| rs2273500 | CHRNA4 | GWAS association (p=8.0e-09) | Meta-analysis |
| rs56247223 | CACNA2D3 | GWAS association (p=4.0e-08) | Meta-analysis |
| rs73229093 | — | GWAS association (p=3.0e-33) | Major Consortium Study |
| rs151176846 | LOC100130587 | GWAS association (p=9.0e-28) | Major Consortium Study |
| rs13036436 | CHRNA4 | GWAS association (p=3.0e-23) | Major Consortium Study |
| rs111596452 | — | GWAS association (p=1.0e-19) | Major Consortium Study |
| rs11783093 | — | GWAS association (p=8.0e-19) | Major Consortium Study |
| rs12042444 | — | GWAS association (p=3.0e-18) | Major Consortium Study |
| rs12440014 | — | GWAS association (p=6.0e-18) | Major Consortium Study |
| rs2138445 | — | GWAS association (p=2.0e-17) | Major Consortium Study |
| rs112270518 | — | GWAS association (p=5.0e-17) | Major Consortium Study |
| rs9646181 | SEMA6D | GWAS association (p=5.0e-16) | Major Consortium Study |
| rs11130204 | — | GWAS association (p=5.0e-15) | Major Consortium Study |
| rs10891480 | NCAM1 | GWAS association (p=3.0e-14) | Major Consortium Study |
| rs2678670 | — | GWAS association (p=2.0e-13) | Major Consortium Study |
| rs61951285 | — | GWAS association (p=5.0e-13) | Major Consortium Study |
| rs295132 | — | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs1004787 | — | GWAS association (p=2.0e-12) | Major Consortium Study |
| rs9287372 | — | GWAS association (p=4.0e-12) | Major Consortium Study |
| rs7581524 | — | GWAS association (p=2.0e-11) | Major Consortium Study |
| rs6499240 | — | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs329121 | — | GWAS association (p=3.0e-11) | Major Consortium Study |
| rs779661 | RANBP17 | GWAS association (p=4.0e-11) | Major Consortium Study |
| rs560500930 | — | GWAS association (p=3.0e-12) | Major Consortium Study |
| rs8034191 | HYKK | GWAS association (p=1.0e-70) | Large GWAS |
| rs1051730 | CHRNA3 | GWAS association (p=6.0e-20) | Large GWAS |
| rs56113850 | CYP2A6 | GWAS association (p=4.0e-16) | Large GWAS |
| rs6011779 | — | GWAS association (p=4.0e-16) | Large GWAS |
| rs56116178 | — | GWAS association (p=2.0e-13) | Large GWAS |
| rs4950 | CHRNB3 | GWAS association (p=2.0e-09) | Large GWAS |
| rs2714674 | — | GWAS association (p=7.0e-09) | Large GWAS |
| rs910083 | DNMT3B | GWAS association (p=4.0e-08) | Large GWAS |
| rs144481999 | — | GWAS association (p=4.0e-08) | Large GWAS |
| rs16969968 | CHRNA5 | Higher nicotine dependence risk | Large GWAS |
Associations aggregated from the GWAS Catalog and curated literature. Informational only — not medical advice.