rs6011779

▶

GWAS Catalog Trait Associations (9)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

smoking behavior trait

Wootton RE et al. “Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study.” Psychological Medicine 50(14):2435-2443 (2020)
Allele C
OR 0.03
p 2.0e-27
N 462,690
Large GWAS
European

leukocyte quantity

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.03
p 6.0e-22
N 381,099
Major Consortium StudyLarge GWAS
European

chronic obstructive pulmonary disease

Zhou W et al. “Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease.” Cell Genomics 2(10):100192 (2022)
Allele T
OR 0.07
p 2.0e-20
N 1,392,366
Meta-analysisLarge GWAS
multi-ancestry
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.06
p 5.0e-20
N 593,956
Major Consortium StudyLarge GWAS
multi-ancestry

nicotine dependence

Quach BC et al. “Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits.” Nature Communications 11(1):5562 (2020)
Allele T
OR 0.03
p 4.0e-16
N 58,000
Large GWAS
multi-ancestry

bronchus cancer

Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele C
OR 0.10
p 6.0e-12
N 447,662
Major Consortium StudyLarge GWAS
European

cigarettes per day measurement

Brazel DM et al. “Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use.” Biological Psychiatry 85(11):946-955 (2019)
Allele T
OR 0.03
p 7.0e-10
N 153,918
Meta-analysisLarge GWAS
European

smoking cessation

Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.02
p 3.0e-41
N 1,147,272
Large GWAS
European
Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele T
OR 0.05
p 1.0e-23
N 547,219
Large GWAS
European
Xu K et al. “Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.” Nature Communications 11(1):5302 (2020)
Allele T
OR 0.95
p 2.0e-21
N 450,129
Meta-analysisLarge GWAS
European

smoking initiation

Liu M et al. “Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.” Nature Genetics 51(2):237-244 (2019)
Allele T
OR 0.01
p 8.0e-15
N 931,815
Large GWAS
European
Saunders GRB et al. “Genetic diversity fuels gene discovery for tobacco and alcohol use.” Nature 612(7941):720-724 (2022)
Allele T
OR 0.02
p 1.0e-9
N 286,026
Large GWAS
Hispanic or Latin American

This variant is in our database but has no known associations or PRS memberships yet.

Gene information from NCBI Gene. Variant classifications from ClinVar.

Community Wiki

No community notes yet for this variant. Sign in to start one.

Comments

Sign in to join the discussion.

Loading comments…