rs35198068
▶GWAS Catalog Trait Associations (29)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (29)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
hemoglobin A1 measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.07
p 7.0e-184
N 415,403
Large GWAS
multi-ancestry
body mass index
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.06
p 4.0e-89
N 424,217
Major Consortium StudyLarge GWAS
European
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.02
p 1.0e-20
N 928,679
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.02
p 2.0e-14
N 523,818
Large GWAS
multi-ancestry
Huang J et al. “Genomics and phenomics of body mass index reveals a complex disease network.” Nature Communications 13(1):7973 (2022)
Allele T
OR 0.03
p 2.0e-8
N 98,277
Large GWAS
multi-ancestry
body weight
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.05
p 3.0e-51
N 288,216
Major Consortium StudyLarge GWAS
European
Jee YH et al. “Genome-wide association studies in a large Korean cohort identify quantitative trait loci for 36 traits and illuminate their genetic architectures.” Nature Communications 16(1):4935 (2025)
Allele T
OR 0.02
p 1.0e-19
N 928,679
Large GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele T
OR 0.02
p 3.0e-13
N 525,535
Large GWAS
multi-ancestry
insulin measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.20
p 4.0e-47
N 442,188
Major Consortium StudyLarge GWAS
European
type 2 diabetes mellitus
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele C
OR 0.33
p 3.0e-41
N 394,626
Large GWAS
European
chloride level
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.04
p 5.0e-39
N 412,365
Major Consortium StudyLarge GWAS
European
diastolic blood pressure change measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 6.0e-36
N 425,743
Major Consortium StudyLarge GWAS
European
erythrocyte count
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 4.0e-33
N 405,366
Major Consortium StudyLarge GWAS
European
Drugs used in diabetes use measurement
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele C
OR 0.28
p 1.0e-32
N 178,726
Large GWAS
East Asian
low density lipoprotein cholesterol measurement
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.03
p 2.0e-30
N 404,745
Major Consortium StudyLarge GWAS
European
▶Research that mentions this SNP (1)
▶Genome‐wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African AmericansAssociationN=6,224Jacob M. Keaton et al.(2018)· Genetic Epidemiology
Genome‐wide interaction with the insulin secretion locus MTNR1B reveals CMIP as a novel type 2 diabetes susceptibility gene in African Americans
AssociationN=6,224Jacob M. Keaton et al.(2018)· Genetic Epidemiology
This genome-wide interaction analysis in 6,224 African Americans identified CMIP rs17197883 as a novel type 2 diabetes susceptibility locus through interaction with the insulin secretion variant MTNR1B rs10830963. The CMIP variant showed antagonistic interaction (P_INTXN = 1.43×10^-8) with opposite effects depending on MTNR1B carrier status: OR = 2.29 (95% CI 1.59-3.28) in AIRg-lowering allele carriers vs. OR = 0.78 (95% CI 0.67-0.90) in non-carriers.
Traits studied:Acute insulin response to glucoseFasting glucoseType 2 diabetes
This variant is in our database but has no known associations or PRS memberships yet.
Gene information from NCBI Gene. Variant classifications from ClinVar.
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