rs35318931

This is a protein-altering variant in the SRPX gene.

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GWAS Catalog Trait Associations (5)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

Inguinal hernia

Choquet H et al. “Ancestry- and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis.” Human Molecular Genetics 31(13):2279-2293 (2022)
Allele A
OR 0.88
p 8.0e-29
N 513,120
Meta-analysisLarge GWAS
multi-ancestry
Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.13
p 8.0e-18
N 623,807
Large GWAS
multi-ancestry

body height

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.02
p 9.0e-24
N 525,444
Large GWAS
multi-ancestry

Varicose veins

Sakaue S et al. “A cross-population atlas of genetic associations for 220 human phenotypes.” Nature Genetics 53(10):1415-1424 (2021)
Allele A
OR 0.13
p 1.0e-13
N 638,428
Large GWAS
multi-ancestry

sex hormone-binding globulin measurement

Ruth KS et al. “Using human genetics to understand the disease impacts of testosterone in men and women.” Nature Medicine 26(2):252-258 (2020)
Allele G
OR 0.01
p 1.0e-11
N 368,929
Large GWAS
European

neuroimaging measurement

Jiang Z et al. “The X chromosome's influences on the human brain.” Science Advances 11(4):eadq5360 (2025)
Allele A
OR 6.68
p 2.0e-11
N 37,772
Large GWAS
European

About SRPX

Predicted to be an extracellular matrix structural constituent. Predicted to be involved in phagolysosome assembly. Predicted to act upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and response to endoplasmic reticulum stress. Located in collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2025]

View all SRPX variants →

Gene information from NCBI Gene. Variant classifications from ClinVar.

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