rs35394392
This variant is located in the SLC4A3 gene.
▶GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (3)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
JT interval
Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)
Allele C
OR 0.05
p 2.0e-42
N 252,730
Large GWAS
European, African unspecified, Hispanic or Latin American, South East Asian, South Asian
QT interval
Young WJ et al. “Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.” Nature Communications 13(1):5144 (2022)
Allele C
OR 0.05
p 1.0e-37
N 252,730
Large GWAS
European, African unspecified, Hispanic or Latin American, South East Asian, South Asian
van Duijvenboden S et al. “Genetic Basis and Prognostic Value of Exercise QT Dynamics.” Circulation. Genomic and Precision Medicine 13(4):e002774 (2020)
Allele C
OR 0.04
p 8.0e-9
N 52,861
Large GWAS
European
van Duijvenboden S et al. “Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders.” Human Molecular Genetics 30(24):2513-2523 (2021)
Allele C
OR 0.05
p 1.0e-12
N 24,495
Large GWAS
European
electrocardiography
Verweij N et al. “The Genetic Makeup of the Electrocardiogram.” Cell Systems 11(3):229-238.e5 (2020)
Allele G
OR 0.04
p 4.0e-8
N 63,706
Major Consortium StudyLarge GWAS
European, NR
▶ClinVar annotation
Benign★★★☆
2 submitters1 publicationAbout SLC4A3
The protein encoded by this gene is a plasma membrane anion exchange protein. The encoded protein has been found in brain, heart, kidney, small intestine, and lung. [provided by RefSeq, May 2016]
View all SLC4A3 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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