rs35624376
This is a intron variant variant in the KLHL8 gene.
▶GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (2)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
liver cancer
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.20
p 2.0e-12
N 631,868
Major Consortium StudyLarge GWAS
multi-ancestry
intrahepatic bile duct cancer, liver cancer
Verma A et al. “Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.” Science (new York, N.y.) 385(6706):eadj1182 (2024)
Allele T
OR 0.18
p 9.0e-12
N 631,416
Major Consortium StudyLarge GWAS
multi-ancestry
About KLHL8
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
View all KLHL8 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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