KLHL8
kelch like family member 8
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Located in nucleoplasm. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]
Known Variants27 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs1730275574 | 4:88,085,105 | T/C | — | uncertain significance |
| rs140341251 | 4:88,085,177 | C/T | — | uncertain significance |
| rs201502223 | 4:88,085,180 | C/T | — | uncertain significance |
| rs144074504 | 4:88,085,192 | C/T | — | uncertain significance |
| rs371718575 | 4:88,091,371 | C/A | — | uncertain significance |
| rs1287981072 | 4:88,091,372 | C/T | — | uncertain significance |
| rs1730583951 | 4:88,091,389 | T/C | — | uncertain significance |
| rs1172061288 | 4:88,091,613 | A/G | — | uncertain significance |
| rs1415125879 | 4:88,091,702 | G/C | — | uncertain significance |
| rs2476516596 | 4:88,091,703 | T/A | — | uncertain significance |
| rs1188291814 | 4:88,097,997 | G/A | — | uncertain significance |
| rs765167374 | 4:88,099,644 | C/A | — | uncertain significance |
| rs1265237538 | 4:88,099,684 | G/C | — | uncertain significance |
| rs2476533838 | 4:88,099,761 | A/G | — | uncertain significance |
| rs143405055 | 4:88,104,471 | T/C | — | uncertain significance |
| rs1321707941 | 4:88,104,486 | T/C | — | uncertain significance |
| rs753972535 | 4:88,104,507 | A/G | — | uncertain significance |
| rs916766394 | 4:88,106,468 | C/T | — | uncertain significance |
| rs759297181 | 4:88,106,609 | T/C | — | uncertain significance |
| rs150632753 | 4:88,106,822 | C/T | — | uncertain significance |
| rs1374619001 | 4:88,106,851 | G/A | — | uncertain significance |
| rs142121618 | 4:88,116,591 | C/A | — | uncertain significance |
| rs373062109 | 4:88,116,684 | G/A | — | uncertain significance |
| rs565455465 | 4:88,135,875 | T/C | — | — |
| rs35624376 | 4:88,159,088 | T/C | intron variant | — |
| rs10029254 | 4:88,160,140 | C/G | — | — |
| rs11929874 | 4:88,162,100 | C/G | — | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.