rs35855737
This is a regulatory region variant variant in the MAGI1 gene.
▶GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (1)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
neuroticism measurement
▶Research that mentions this SNP (1)
▶Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive DisorderMeta-analysisN=63,661Marleen H. M. de Moor et al.(2015)· JAMA Psychiatry
Genome-wide meta-analysis of 63,661 participants identified a novel genome-wide significant locus rs35855737 (P=9.26×10⁻⁹) in the MAGI1 gene associated with neuroticism. Common SNPs explained approximately 15% of neuroticism variance. Polygenic risk scores based on neuroticism associations significantly predicted both neuroticism (variance explained 0.66%, P=1.09×10⁻¹²) and Major Depressive Disorder status (variance explained 1.05%, P=4.02×10⁻⁹), demonstrating shared genetic architecture between these traits.
About MAGI1
The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
View all MAGI1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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