rs3741240
This is a downstream gene variant variant in the SCGB1A1 gene.
▶GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
GWAS Catalog Trait Associations (5)
Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.
level of secretoglobin family 3A member 1 in blood serum
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.12
p 3.0e-125
N 47,745
Large GWAS
European
level of secretoglobin family 3A member 2 in blood
Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)
Allele A
OR 0.12
p 7.0e-107
N 47,745
Large GWAS
European
CC16 measurement
Milne S et al. “Protective effect of club cell secretory protein (CC-16) on COPD risk and progression: a Mendelian randomisation study.” Thorax 75(11):934-943 (2020)
Allele G
OR 0.18
p 2.0e-59
N 5,552
Large GWAS
chronic obstructive pulmonary disease, CC16 measurement
Kim DK et al. “Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.” American Journal of Respiratory and Critical Care Medicine 186(12):1238-47 (2012)
Allele A
OR —
p 1.0e-26
N 1,951
Large GWAS
European
blood protein amount
Gudjonsson A et al. “A genome-wide association study of serum proteins reveals shared loci with common diseases.” Nature Communications 13(1):480 (2022)
Allele A
OR 0.15
p 2.0e-13
N 5,360
Large GWAS
European
▶ClinVar annotation
About SCGB1A1
This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
View all SCGB1A1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
Community Wiki
No community notes yet for this variant. Sign in to start one.
Comments
Sign in to join the discussion.
Loading comments…