rs3745523
This is a upstream gene variant variant in the KLK15 gene.
▶Research that mentions this SNP (1)
▶Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, ChinaAssociationN=244Min Shen et al.(2009)· Environmental and Molecular Mutagenesis
A case-control study of 122 cases and 122 controls in Xuanwei, China examined 1,173 SNPs in 149 innate immunity gene regions for associations with lung cancer risk in a population exposed to high levels of coal smoke. FCER2 rs7249320 showed the strongest association (OR=0.30, 95% CI: 0.16-0.55, P<0.0001), while KLK2 rs2739476 and ALOX12B rs6503075 showed >2-fold increased risk. Significant interactions were found between KLK15 rs3745523 and coal exposure, and between FCER2 rs7249320 and KLK2 rs2739476 (OR=10.77, P=0.003).
About KLK15
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
View all KLK15 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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