KLK15
kallikrein related peptidase 15
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. The gene contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Known Variants24 total
| rsid | Position (GRCh37) | Alleles | Class | ClinVar |
|---|---|---|---|---|
| rs537025251 | 19:51,329,064 | C/T | — | uncertain significance |
| rs143488632 | 19:51,329,075 | T/C | — | uncertain significance |
| rs2513872978 | 19:51,329,107 | T/C | — | uncertain significance |
| rs528884067 | 19:51,329,117 | G/C | — | likely benign |
| rs201054965 | 19:51,329,141 | C/T | — | uncertain significance |
| rs113529853 | 19:51,329,146 | C/T | missense variant | — |
| rs771040569 | 19:51,329,158 | A/G | — | uncertain significance |
| rs533671865 | 19:51,329,921 | T/C | — | uncertain significance |
| rs1568483222 | 19:51,329,936 | G/A | — | uncertain significance |
| rs3212852 | 19:51,330,129 | C/T | splice region variant | — |
| rs762030515 | 19:51,330,146 | G/A | — | uncertain significance |
| rs202125732 | 19:51,330,256 | G/C | — | uncertain significance |
| rs753810753 | 19:51,330,260 | T/G | — | uncertain significance |
| rs2089897815 | 19:51,330,373 | T/C | — | uncertain significance |
| rs374766999 | 19:51,330,377 | G/T | — | uncertain significance |
| rs370799428 | 19:51,330,927 | C/T | — | uncertain significance |
| rs3745522 | 19:51,330,932 | G/T | synonymous variant | — |
| rs770919141 | 19:51,330,984 | C/T | — | uncertain significance |
| rs931680217 | 19:51,331,017 | T/C | — | uncertain significance |
| rs753191173 | 19:51,331,060 | C/T | — | uncertain significance |
| rs545571047 | 19:51,333,293 | A/C | — | — |
| rs3745523 | 19:51,334,890 | C/T | upstream gene variant | — |
| rs2659056 | 19:51,335,943 | T/C | upstream gene variant | — |
| rs11666508 | 19:51,337,593 | C/T | upstream gene variant | — |
Gene information from NCBI Gene. Variant classifications from ClinVar.