rs3757769
This is a intron variant variant in the SND1 gene.
▶Research that mentions this SNP (1)
▶Single nucleotide polymorphisms in transcription factor genes associated with susceptibility to oral cancerAssociationN=1,000Hetal Damani Shah et al.(2020)· Journal of Cellular Biochemistry
Case-control study of 500 oral cancer patients and 500 healthy tobacco users from India identifying 5 SNPs in transcription factor genes associated with increased oral cancer risk: rs2051526 (ETV6, OR=1.98), rs6021247 (NFATC2, OR=2.77), rs3757769 (SND1, OR=2.09), rs7085532 (TCF7L2, OR=12.16), and rs7778413 (SND1, OR=34.60). Coinheritance of rs6021247 GG and rs7778413 CC genotypes showed dramatic increased risk (OR=49.94).
About SND1
This gene encodes a transcriptional co-activator that interacts with the acidic domain of Epstein-Barr virus nuclear antigen 2 (EBNA 2), a transcriptional activator that is required for B-lymphocyte transformation. Other transcription factors that interact with this protein are signal transducers and activators of transcription, STATs. This protein is also thought to be essential for normal cell growth. A similar protein in mammals and other organisms is a component of the RNA-induced silencing complex (RISC). [provided by RefSeq, Jul 2016]
View all SND1 variants →Gene information from NCBI Gene. Variant classifications from ClinVar.
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