rs3762055

This is a regulatory region variant variant in the ORM2 gene.

▶

GWAS Catalog Trait Associations (2)

Genome-wide significant associations (p < 5×10⁻⁸) from the NHGRI-EBI GWAS Catalog.

vascular endothelial growth factor D measurement

Loya H et al. “A scalable variational inference approach for increased mixed-model association power.” Nature Genetics 57(2):461-468 (2025)

Allele C

OR 0.10

p 2.0e-19

N 47,745

Large GWAS

European

serine protease inhibitor Kazal-type 2 measurement

Pietzner M et al. “Mapping the proteo-genomic convergence of human diseases.” Science (new York, N.y.) 374(6569):eabj1541 (2021)

Allele T

OR 0.21

p 2.0e-12

N 10,708

Large GWAS

European

▶

Research that mentions this SNP (2)

▶

Influence of ORM1 polymorphisms on the maintenance stable warfarin dosage

AssociationN=191Lian Sheng Wang et al.(2013)· European Journal of Clinical Pharmacology

This study examined 191 Chinese patients on warfarin therapy to determine whether the ORM1 rs17650 polymorphism influences warfarin maintenance dosage. Results showed that warfarin dose was significantly correlated with VKORC1 rs7294, CYP2C9 rs1057910, and ORM1 rs17650 polymorphisms (all P<0.05), with these three genes explaining 24% of dosage variation. ORM1 *S/*S and *F1/*S carriers required approximately 10-17% lower warfarin doses compared to wild-type *F1/*F1 patients.

Traits studied:Warfarin anticoagulation responseWarfarin maintenance dosage

PubMed DOI Metascience Observatory

▶

Association of warfarin dose with genes involved in its action and metabolism

AssociationN=201Mia Wadelius et al.(2007)· Human Genetics

An association study of 201 warfarin-treated patients found that polymorphisms in VKORC1, CYP2C9, CYP2C18, CYP2C19, PROC, and APOE were significantly associated with warfarin dose requirement (P < 0.000175 for VKORC1 and CYP2C9). A multiple regression model incorporating VKORC1, CYP2C9, PROC, and non-genetic factors (age, bodyweight, drug interactions, treatment indication) accounted for 62% of the variance in warfarin dose.

Traits studied:Warfarin dose requirement

PubMed DOI Metascience Observatory

About ORM2

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]